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Adrenal Insufficiency

October 31, 2011  by: Dr. Simran Kaur  Points: 8   Category: Health  Earning $0.15   Views: 442

It results from inadequate secretion of cortisol and aldosterone.

         

It results from inadequate secretion of cortisol and aldosterone.

Causes -

1. Hypothalamic disease.

2. Pituitary disease.

3. Decrease in adrenocorticotrophin hormone.

4. Addison's disease.

5. Congenital hyperplasias.

6. Drugs.

7. Corticosteroid biosynthetic enzyme defects.

Symptoms-

1. In addison's disease, either glucocorticoid or mineralocorticoid deficiency may come first.

2. Acute circulatory shock.

3. Adrenocortical insufficiency.

4. Hyponatraemia.

5. Acute adrenal crisis.

6. Muscle cramps.

7. Nausea.

8. Vomiting.

9. Diarrhea.

10. Fever.

11. Vitiligo.

Investigations-

1. Random plasma cortisol test.

2. Short Adrenocorticotrophin Hormone Stimulation test.

3. Long Adrenocorticotrophin Hormone Stimulation test.

4. Thyroid function tests.

5. Full blood count.

6. Plasma calcium.

7. Chest x-ray.

8. Adrenal CT.

9. Adrenal MRI.

Management-

1. Glucocorticoid replacement therapy.

2. Mineralocorticoid replacement therapy.




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