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Liver Transplantation

November 03, 2011  by: Dr. Simran Kaur  Points: 5   Category: Health  Earning $0.10   Views: 432

Liver transplantation in cirrhosis is considered when the anticipated mortality without transplantation exceeds 50% at 1 year.

         

Liver transplantation in cirrhosis is considered when the anticipated mortality without transplantation exceeds 50% at 1 year.

Main contradictions to liver transplantation are-

1. Sepsis.

2. Extrahepatic malignancy.

3. Alcohol.

4. Marked cardio respiratory dysfunction.

Complications of liver transplantation-

1. Acute rejection occurs in up to 60% of patients, usually within the first 6 weeks after transplantation.

2. Surgical complications include hepatic artery thrombosis.

3. Bacterial infections such as pneumonia and wound infections can occur in the first few weeks after transplantation.

4. Late complications include recurrence of the initial disease in the graft and complications due to the immunosuppressive therapy.

The outcome following transplantation for acute liver failure is worse than for chronic liver disease.




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