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Chronic Lymphocytic Leukemia

November 08, 2011  by: Dr. Simran Kaur  Points: 8   Category: Health  Earning $0.20   Views: 365

In this disease B lymphocytes, which would normally respond to antigens by transformation and antibody formation, fail to do so.

         

In this disease B lymphocytes, which would normally respond to antigens by transformation and antibody formation, fail to do so. An ever increasing mass of immune-incompetent cells accumulate, to the detriment of immune function and normal bone marrow haematopoiesis.

Symptoms-

1. Insidious onset.

2. Anemia.

3. Infections.

4. Painless lymphadenopathy.

5. Night sweats.

6. Weight loss.


Investigations-

1. Peripheral blood findings.

2. Immunophenotyping.

3. Reticulocyte count.

4. Direct Coombs test.

5. Serum immunoglobulin levels.

6. Bone marrow examination.

7. CD38 expression.

8. Mutations of IgVH genes.

9. Cytogenetic abnormalities of chromosome 11 or 17 may also suggest a poorer prognosis.


Management-

1. Treatment is only required if there is evidence of bone marrow failure, massive or progressive lymphadenopathy or splenomegaly, systemic symptoms.

2. Chemotherapy.

3. Corticosteroid therapy.

4. Transfusions for symptomatic anemia.

5. Treat infections.

6. Immunoglobulin replacement.

7. Radiotherapy.

8. Splenoectomy.




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