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Sarcoidosis

July 31, 2012  by: Dr. Simran Kaur  Points: 7   Category: Health  Earning $0.20   Views: 262

Sarcoidosis more frequently affects lung although it can affect other organs like lymph nodes, eyes, skin, parotid gland, liver, spleen and kidneys.

         

Sarcoidosis is a multisystem, chronic granulomatous inflammatory disease. It can affect any part of body. The cause of this disease is unknown but usually exaggerated cellular immune response to a limited type of antigens or self-antigens is considered as a basic factor for its causation.

Sarcoidosis more frequently affects lung although it can affect other organs like lymph nodes, eyes, skin, parotid gland, liver, spleen and kidneys.

Symptoms-

1. There are non-caseating epithelioid granulomas.

2. Sometimes, sarcoidosis shows no symptoms and remains asymptomatic and constitutes about thirty to forty percent of cases of sarcoidosis which remains asymptomatic.

3. In acute or sub-acute form, there is fever, fatigue, anorexia and weight loss. Cough, dyspnoea and retrosternal chest discomfort is also there. Sometimes Lofgren’s syndrome or Heerfordt-Waldenstrom syndrome is also there.

4. In chronic cases, there are respiratory symptoms but there are no constitutional symptoms. There may be symptoms of interstitial lung disease or atelectasis. Cavitation and unilateral pleural effusion is also there.

Investigations-

1. WBC, TLC test.

2. ESR test.

3. Serum calcium level test.

4. Urine test.

5. Plasma level of angiotensin converting enzyme.

6. Mantoux test.

7. Kveim test.

8. Chest X-ray.

9. CT scan of chest.

10. Pulmonary function tests.

11. Bronchoalveolar lavage.

12. Transbronchial biopsy.

13. MRI of brain and heart.




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