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Sickle Cell Anaemia

August 09, 2012  by: Dr. Simran Kaur  Points: 8   Category: Health  Earning $0.20   Views: 419

Sickle cell anaemia is caused due to the presence of abnormal haemoglobin known as sickle cell haemoglobin or haemoglobin-S or Hb-S.

         

Sickle cell anaemia is caused due to the presence of abnormal haemoglobin known as sickle cell haemoglobin or haemoglobin-S or Hb-S. Sickle cell anemia is homozygous state for the Hb-S gene that is Hb-SS, which is transmitted as an autosomal recessive disease whereas Hb-AS which is heterozygous state for the Hb-S gene is known as sickle cell trait.

Symptoms-

1. Children with sickle cell disease are asymptomatic in first six months of life.

2. Pneumococcal meningitis, pneumonia, septicaemia in children.

3. Hand foot syndrome, splenic sequestration syndrome in children.

4. Splenomegaly in early childhood but due to repeated attacks splenic infarction ultimately leads to atrophy of spleen.

5. Acute chest syndrome in both children and adults.

6. In adults, there is anaemia, infarction crisis in various organs due to which there is sudden attacks of bone pain and abdominal pain, hemiplegia, haematuria.
7. Aplastic crisis.

8. Haemolytic crisis in which there is increased sequestration and destruction of red cells which results in abrupt decrease in haemoglobin level and rapid enlargement of liver and spleen.

9. Stroke, chronic leg ulcers, frontal bossing of skull, prominent malar bones and protuberant teeth.


Investigations-

1. Hb test.

2. Peripheral blood smear test.

3. Sickle test.

4. Haemoglobin solubility test.

5. Haemoglobin electrophoresis.




Comment(s)
Author: SandeepSunnyJasrotia        
Posted Date: 08/12/2012    Points:1    

Informative share...This is the info that everyone should know..Thanks simi...:)

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