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Causes of Massive Splenomegaly

August 09, 2012  by: Dr. Simran Kaur  Points: 12   Category: Health  Earning $0.30   Views: 736

Splenomegaly is enlargement of spleen than its normal size. It is of different types. One type of which is massive splenomegaly.


Splenomegaly is enlargement of spleen than its normal size. It is of different types. One type of which is massive splenomegaly. Massive splenomegaly is caused due to different reasons. It is not disease itself but is symptom of various diseases.

The main causes of massive splenomegaly are-

1. Chronic myeloid leukaemia.

2. Myelofibrosis.

3. Extra hepatic portal hypertension.

4. Tropical splenomegaly.

5. Lymphomas.

6. Cysts and tumors of spleen.

1. Chronic myeloid leukaemia-

Massive splenomegaly is also found in chronic myeloid leukaemia. It affects people of fifty five years of age. Anemia with hepatomegaly is there. Philadelphia chromosome is positive in most of the cases of chronic myeloid leukaemia.

2. Myelofibrosis-

Myelofibrosis usually remains asymptomatic for many years. In symptomatic period, there is anemia, massive splenomegaly and hepatomegaly. Haemoglobin is reduced in later stage of disease. Increase in bone density of vertebrae and proximal ends of long bones are there.

3. Extra-hepatic portal hypertension-

Also shows symptoms of massive splenomegaly along with the symptoms of haematemesis and portal hypertension.

4. Tropical splenomegaly-

Tropical splenomegaly occurs due to abnormal immune response to repeated malarial infections. Low grade fever with massive splenomegaly and hepatomegaly is there.

5. Lymphomas also show symptom of massive splenomegaly along with other symptoms of lymphoma.

6. Cysts and tumors of spleen also show symptoms of massive splenomegaly along with other symptom of disease.

Author: SandeepSunnyJasrotia        
Posted Date: 08/13/2012    Points:2    

I palpated spleen of one child in the hospital....He also had splenomegaly in the initial stage..Your post makes me remember of that patient...Thanks..

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