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Systemic Sclerosis

September 02, 2012  by: Dr. Simran Kaur  Points: 12   Category: Health  Earning $0.15   Views: 536

Systemic sclerosis is a disease which affects skin, gastro-intestinal tract, musculoskeletal system, lungs, heart and kidneys. Hence, it is a multisystem disorder.


Systemic sclerosis is a disease which affects skin, gastro-intestinal tract, musculoskeletal system, lungs, heart and kidneys. Hence, it is a multisystem disorder. It can be located in specific area without the systemic involvement. In systemic form of disease, it causes diffuse cutaneous systemic sclerosis and limited cutaneous systemic sclerosis.


1. Raynaud’s phenomena.

2. Diffuse cutaneous scleroderma in which there occurs rapid symmetrical skin thickening of proximal and distal extremities, face and trunk.

3. Limited cutaneous scleroderma in which there occurs skin thickening limited to only distal extremities and face.

4. Pulmonary arterial hypertension in some cases.

5. Biliary cirrhosis in some cases in advanced stage of disease.

6. Muscle weakness, arthralgia of fingers and knees, symmetric polyarthritis.

7. Non-pitting oedema in early phase of disease whereas in advanced stage skin becomes firm, thickened and eventually tightly bound to underlying subcutaneous tissue.

8. Dysphagia, reflux oesophagitis, sliding hiatus hernia.

9. Dilatation, atony and delayed gastric emptying.

10. Flatulent abdomen with abdominal pain, constipation and intestinal obstruction.

11. Pulmonary fibrosis, pericarditis, arrhythmias.

12. Renal failure.


1. ESR test.

2. Hb test.

3. Peripheral blood smear test.

4. RA factor test.

5. Serological or immunological test.

6. Barium swallow test.

7. Chest x-ray test.

8. CT scan of chest.

9. Pulmonary function tests.

10. Echocardiography test.


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