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Causes and Symptoms of Gout

September 06, 2012  by: Dr. Simran Kaur  Points: 12   Category: Health  Earning $0.15   Views: 486

Gout is inflammatory disease of joints in which there occurs increase in serum uric acid concentration more than the normal value, which cause inflammation of joints which further leads to arthritis.

         

Gout is inflammatory disease of joints in which there occurs increase in serum uric acid concentration more than the normal value, which cause inflammation of joints which further leads to arthritis.

In gout, serum uric acid concentration gets increased more than 7 mg/dL in males and more than 6mg/dL in females.

Causes-

1. Increased production of uric acid.

2. Decreased renal excreation of uric acid.

3. Glucose-6-phosphate deficiency.

4. Idiopathic causes.

5. Myeloproliferative diseases.

6. Lymphoproliferative diseases.

7. Side effects of cancer chemotherapy.

8. Renal failure.

9. Lead poisoning.

10. Side effects of some medicines.

11. Hyperparathyroidism.

12. Myxoedema.

13. Alcohol.

14. Down’s syndrome.


Symptoms-

1. Increase in serum uric acid concentration more than 7 mg/dL in males whereas in females more than 6 mg/dL.

2. Recurrent episodes of acute arthritis.

3. Crystals of monosodium urate monohydrate are found in leucocytes of synovial fluid.

4. Aggregated deposits of monosodium urate monohydrate found in and around the joints.

5. Uric acid nephrolithiasis.

6. Sometimes insidious onset of disease and sometime sudden onset of disease.

7. In seventy percent of cases of gout, metatarsophalangeal joint of great toe is affected first. Other joints which are affected by gout are tarsal joints, ankles, knees and wrists.

8. The affected joint is red, hot, swollen and painful.

9. Loss of appetite, nausea, fever.

10. Leucocytosis.

11. Urate nephropathy.

12. Formation of urate calculi.

13. Parenchymal renal damage.


Investigations-

1. Serum uric acid test.

2. Synovial fluid test.

3. ESR test.

4. TLC, DLC tests.

5. X-ray of affected joints.




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