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Symptoms of Thiamine Deficiency

September 25, 2012  by: Dr. Simran Kaur  Points: 8   Category: Health  Earning $0.20   Views: 461

Vitamin B1 also known as thiamine is very important vitamin from series of different types of B vitamins. What happens if there occur deficiency of thiamine in the body?


Vitamin B1 also known as thiamine is very important vitamin from series of different types of B vitamins. Vitamin B1 is required for the co-enzyme named thiamine pyrophosphate. It helps in decarboxylation of pyruvate to acetyl CoA and also helps in decarboxylation of alpha ketoglutarate to succinate. It is also required for transketolase in the hexose monophosphate shunt pathway.

So this was about benefits of thiamine in metabolic pathway of body. What happens if there occur deficiency of thiamine in the body? Thiamine deficiency causes following symptoms in body which are as follow-

1. Defective aerobic cellular glucose utilization.

2. Pyruvic acid and lactic acid accumulation which causes vasodilatation and increased cardiac output.

3. Wet beriberi syndrome in which there occurs high cardiac output whereas in dry beriberi syndrome there occurs peripheral neuropathy.

4. Wernicke’s encephalopathy.

5. Korsakoff’s psychosis.

6. Wet beriberi syndrome is caused by eating diet deficient in vitamin B1. It usually occurs when diet consists mainly of polished, highly milled rice which are devoid of vitamin B1.

7. Oedema with peripheral vasodilatation.

8. Warm extremities are there.

9. Sodium and water retention is there with venous congestive stage and marked cardiomegaly and tender hepatomegaly in beriberi heart disease caused due to deficiency of vitamin B1.


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